He studied Architecture and Urbansim at the Technical University Darmstadt and the Accademia del Arte in Florence.
From 1992 on he initiated several project- and office partnerships, amongst others with Zamp Kelp and Julius Krauss, later on with Bernd Kniess (b&k+).
During this period, among others, the projects Neanderthal Museum (Mettmann, 1996) and the Kölner Brett (Cologne, 2000); and numerous publications have been realized.
He is the founder of brandlhuber+ (2006) and Brandlhuber+ Emde, Burlon a collaborative practice with Markus Emde and Thomas Burlon based in Berlin since 2009.
The projects during this period include the Haus Brunnenstrasse 9 (Berlin, 2009), the Antivilla (Krampnitz, 2014) and St. Agnes (Berlin, 2015).
Arno Brandlhuber teaches at several universities and colleges.
Since 2003 he holds the chair of architecture and urban research at the Academy of Fine Arts, Nuremberg and is directing the nomadic masters program: a42.org.
He was a guest teacher at several universities including Technische Universität Wien, ETH Zurich and Harvard Graduate School of Design.
Besides his building practice he is researching the spatial production of the Berlin Republic, including several exhibitions and a recently published book on Berlin entitled The Dialogic City: Berlin wird Berlin.
In addition he deals with the subject of „the legislative" in architecture as a determining factor in both, his building practice as well as an architecture-theoretical discourse.
His practice has been included in the 9th, 10th, 11th, 13th and 15th Architecture Biennale. The latter shows the collaborative movie Legislating Architecture by Arno Brandlhuber + Christopher Roth.